Table 1.

Pharmacokinetics of cisplatin and its analogues following intravenous infusion. Reprinted with permission from [19]. Copyright Springer 2000.

	Cisplatin	Carboplatin	Oxaliplatin
t1/2α (min)
Total Platinum	14–49	12–98	26
Ultrafiltrate	9–30	8–87	21
t1/2β (h)
Total Platinum	0.7–4.6	1.3–1.7
Ultrafiltrate	0.7–0.8	1.7–5.9
t1/2γ (h)
Total Platinum	24–127	8.2–40	38–47
Ultrafiltrate			24–27
Protein Binding (%)	>90	24–50	85
Urinary Excretion (%)	23–50	54–82	>50

t_1/2α, t_1/2β, and t_1/2γ = early, mid, and late half-lives.