Table 3.
In vitro susceptibilities of Candida BSI.
| BSI | ||||||||
|---|---|---|---|---|---|---|---|---|
| Species | Drug | MIC (mg/L) | ECV (mg/L) a | Susceptibility | ||||
| MIC Range | MIC50 | MIC90 | S | I/SDD | R | |||
| C. albicans (31) | AMB | 0.25–1 | 0.5 | 0.5 | 1 | 31 | - | - |
| CAS | 0.016–0.5 | 0.031 | 0.125 | 0.25 | 30 | 1 | - | |
| MCF | ≤0.008–0.03 | ≤0.008 | 0.016 | 0.06 | 22 | - | - | |
| FZ | 0.12–1 | 0.25 | 0.5 | 1 | 31 | - | - | |
| VOR | ≤0.008–0.03 | ≤0.008 | 0.016 | 0.016 | 31 | - | - | |
| C. parapsilosis (45) | AMB | 0.25–1 | 0.5 | 0.5 | 1 | 45 | - | - |
| CAS | 0.125–1 | 0.25 | 0.5 | 2 | 44 | - | - | |
| MCF | 0.25–2 | 1 | 1 | 4 | 32 | - | - | |
| FZ | 0.25–8 | 1 | 2 | 2 | 41 | 3 | 1 | |
| VOR | ≤0.008–0.06 | ≤0.016 | 0.03 | 0.016 | 44 | - | - | |
| C. glabrata (11) | AMB | 0.5–1 | 0.5 | 1 | 1 | 11 | - | - |
| CAS | 0.016–1 | 0.06 | 0.25 | 0.25 | 9 | 1 | 1 | |
| MCF | ≤0.008 – 0.016 | 0.016 | 0.25 | 0.03 | 9 | - | 2 | |
| FZ | 2–64 | 4 | 16 | 64 | 10 | - | 1 | |
| VOR | 0.016–1 | 0.06 | 0.5 | 2 | 11 | - | - | |
| C. krusei (7) | AMB | 0.5–1 | 1 | 1 | 128 | 6 | - | - |
| CAS | 0.125–0.25 | 0.25 | 0.25 | 1 | 7 | - | - | |
| MCF | 0.06–0.125 | 0.06 | 0.125 | 0.25 | 5 | - | - | |
| VOR | 0.06–0.5 | 0.25 | 0.25 | 0.25 | 7 | - | - | |
| C. tropicalis (6) | AMB | 0.25–1 | 0.5 | 1 | 1 | 6 | - | - |
| CAS | 0.016–0.06 | 0.03 | 0.06 | 0.25 | 6 | - | - | |
| MCF | 0.016–0.03 | 0.03 | 0.03 | 0.06 | 4 | - | - | |
| FZ | 0.5–2 | 1 | 1 | 2 | 6 | - | - | |
| VOR | 0.03–0.125 | 0.06 | 0.125 | 0.5 | 6 | - | - | |
| Other spp. b (22) | AMB | 0.125–1 | 0.25 | 0.5 | NA | 16 | - | - |
| CAS | 0.016–1 | 0.25 | 1 | NA | 22 | - | - | |
| MCF | 0.03–1 | 0.06 | 0.125 | NA | 16 | - | - | |
| FZ | 0.25–32 | 1 | 4 | NA | 20 | - | 2 | |
| VOR | ≤0.008–0.125 | 0.016 | 0.125 | NA | 22 | - | - | |
| All spp. (122) | AMB | 0.125–1 | 0.5 | 1,0 | NA | 115 | - | - |
| CAS | 0.016–1 | 0.25 | 0.5 | NA | 121 | 1 | 1 | |
| MCF | ≤0.008–2 | 0.06 | 1 | NA | 89 | - | 2 | |
| FZ | 0.12–64 | 1 | 4 | NA | 115 | 3 | 4 | |
| VOR | ≤0.008–0.125 | 0.016 | 0.12 | NA | 121 | - | - | |
AMB: Amphotericin B; CASL: Caspofungin; MCF: Micafungin; FZ: Fluconazole; VOR: Voriconazole; NWT: Non-wild type; S: Susceptible; SDD: Susceptible dose dependent; I: Intermediate; R: Resistant; a ECVs: Epidemiological cutoff values for 97.5% of the population, based on MICs obtained by SYO; b other species include C. lusitaniae (n = 19); C. guilliermondii (n = 2); and C. famata (n = 1).