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. 2021 Jan 22;13(2):162. doi: 10.3390/v13020162

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Glioblastomas; histological and immunohistochemical characterization. Low magnification views of glial tumors originating in the cortex of transgenic mice. These tumors exhibit prominent areas of necrosis (Panel (A), H&E), and T-Antigen expression (Panel (B), both panels original magnification 100×). Histologically, these aggressive tumors were composed of numerous irregular malignant cells with highly atypical and pleomorphic nuclei and abundant cytoplasm. Numerous giant multinucleated cells, mitotic figures and areas of necrosis are observed (Panel (C), hematoxylin and eosin). Robust cytoplasmic immunoreactivity for GFAP is present in practically all neoplastic cells confirming the astrocytic phenotype (Panel (D)). Expression of T-Antigen (Panel (E)) and p53 is found in the nuclei of neoplastic astrocytes (Panel (F)). (Panels (C)–(F) original magnification ×400).