Figure 2.

Pharmacokinetics (a,b) and changes in blood glucose (c) associated with delivering a single dose of BYL719 in the diet or via gavage in male mice. Plasma BYL719 (d) and food intake (e) of mice fed a control (Veh; vehicle) or BYL719 (BYL) containing diet for one week. Data are presented as mean ± SE, statistical analysis for (a,b) was by two-way repeated measures ANOVA with Sidak post-hoc, (d) by linear regression, and (e) by t-test. **** p < 0.001 vs. Veh at same time point. N = 6 per group for (a–d).