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Glucose (a,b) and insulin tolerance tests (c,d), and blood glucose response to a meal challenge (e,f) of male and female middle-aged mice following 6 weeks of receiving a control- (Veh; vehicle) or BYL719 (BYL)-containing diet. Data are presented as mean ± SE, statistical analysis was by two-way repeated measures ANOVA with Sidak post-hoc. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. Veh.
