Figure 3.

Effect of methionine restriction on longevity and age-related pathologies. Methionine restriction may be one of the dietary interventions involved in longevity and the amelioration of age-related pathologies, including metabolic disease and cancer growth, partially through the enhancement of antioxidative defenses and attenuation of oxidative stress. Several diet patterns, such as the vegan diet, the DASH diet, ketogenic diet (fat based) and Japanese diet (carbohydrate based), may be candidates for a dietary pattern that restricts methionine intake. ↑: upregulation, ↓: downregulation.