Table 5.
Combinatory effects of LdRe and LnRe with cefotaxime. The results are showed as MIC and MIC combination (MICcomb; expressed in μg/mL), fractional inhibitory concentration (FIC), fractional inhibitory concentration index (FICI) and dose reduction index (DRI) values.
| MSSA | MRSA | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC | MICcomb | FIC | FICI | DRI | Effect | MIC | MICcomb | FIC | FICI | DRI | Effect | |
| LdRe | 32 | 16 | 0.5 | 1 | 2 | Ind | 32 | 32 | 1 | 1.25 | 4 | Ind |
| Cef | 1 | 0.5 | 0.5 | 0.5 | 0.125 | 0.25 | ||||||
| LnRe | 32 | 32 | 1 | 1.25 | 4 | Ind | 16 | 8 | 0.5 | 1 | 2 | Ind |
| Cef | 1 | 0.25 | 0.25 | 0.5 | 0,25 | 0.5 | ||||||
MSSA: Methicillin-sensitive Staphylococcus aureus ATCC 25923; MRSA: Methicillin-resistant S. aureus ATCC 43300; MIC: Minima Inhibitory Concentration; MICcomb: Minima Inhibitory Concentration combination; FIC: Fractional Inhibitory Concentration; FICI: Fractional Inhibitory Concentration Index; DRI: Dose Reduction Index; Ind: indifference. Synergy (FICI ≤ 0.5), no interaction or indifference (FICI > 0.5–4.0) and antagonism (FICI > 4).