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Sites of vulnerability on the HIV-1 Env trimer. Cartoon representation of the Env trimer composed of three gp120 (yellow) and three gp41 subunits (grey) as displayed at the viral membrane (brown). Epitope locations of common bnAbs are shown as color-coded dashed line circles. Footprints of bnAbs on an actual X-ray crystal structure of the HIV Env are also presented in recent reviews [88].
