Table 3.
Clinical workflow of migraine subjects who developed NTG-induced headache attack and completed the study.
| Subject ID | Anamnestic Migraine Features ˄ | Presence of Not Specific Headache after NTG Administration ∫ | MRI Scan 1, Minutes Post NTG | Premonitory Features at Prodromal Scan † | MRI Scan 2, Minutes Post Induction | NRS */ Pain Side at Full Blown « | Migraine Features during Full Blown Scan ˄ | Self Reported Resemblance with Typical Migraine Attack ~ | MRI Scan 3, Minutes at Recovery after NSAID | NRS * Recovery |
|---|---|---|---|---|---|---|---|---|---|---|
| EM1 | 0/0/1/1/1/1 | 1 | 80 | 0/0/0/1/0/0/0/0/0/1/0 | 200 | 7/R | 0/0/1/1/1/1 | 1 | 85 | 1 |
| EM2 | 0/0/1/0/1/1 | 1 | 31 | 1/0/0/1/1/0/0/0/0/0/0 | 140 | 5/R | 0/0/1/0/1/1 | 1 | 50 | 0 |
| EM3 | 1/1/1/1/0/1 | 1 | 110 | 0/0/0/0/1/0/0/0/1/1/0/0 | 155 | 6/L | 1/0/1/1/0/1 | 1 | 70 | 1 |
| EM4 | 1/0/1/0/1/1 | 0 | 38 | 1/1/0/0/0/0/0/1/0/0/0/0 | 70 | 8/B | 1/0/1/0/1/1 | 1 | 95 | 0 |
| EM5 | 0/0/1/1/1/1 | 0 | 65 | 0/0/0/0/1/0/0/1/1/0/0 | 105 | 6/B | 1/0/1/1/1/1 | 0 | 106 | 1 |
| Median | 65 | 140 | 6 * | 85 | 1 * | |||||
˄ 1 = presence of the characteristics of migraine attack: (0 = no; 1 = yes) nausea/vomiting/photophobia/phonophobia/aggravation by movement/throbbing pain. ∫ a specific headache: 1 = presence of transient olocranic headache after NTG administration, not resembling a migraine attack neither fulfilling ICHD-III criteria. † 1 = presence of prodromal signs or symptoms: (0 = no; 1 = yes) yawning/irritability/mood swing/sleepiness/tiredness/loss of appetite/food desire/nausea/stiffness/thirst/urinary retention. * NRS: numeric pain rating score 0–10 (mild: 1–3; moderate: 4–6; severe: 7–10). ~ 1 = self-reported resemblance between her/his typical migraine attack and the NTG-induced headache attack (0 = no; 1 = yes). « R = right; L = left; B = bilateral.