Figure 5.

Pre–treatment with 10µM punicalagin (PUN) for 24 h downregulated the H₂O₂–induced caspase–3 activity in ARPE–19 cells. Data are expressed as a percentage relative to the untreated cells (control = 100%) and are presented as the means ± SEM of 6 replicates per group from two independent experiments. One–way ANOVA analysis was carried out followed by post hoc Newman–Keuls test. *** p < 0.001 vs. Control; °°° p < 0.001 vs. H₂O₂ alone.