Figure 2.

Key cellular functions potentially regulated by active GSK3β in adult stem cells: Survival (green) and plasticity (blue) are promoted and metabolism/proliferation/differentiation (red) are decreased. Depending on the environment, signal transduction at the plasma membrane can trigger GSK3β activation, by the inhibition of its kinase-dependent phosphorylation or the activation of its phosphatase-dependent de-phosphorylation, for example [1]. Inside the cell, active GSK3β can be found in different molecular complexes and its trafficking between them is poorly known. These pools of GSK3β can be independently activated or inhibited and little is known on their coordinated activation.