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Potential impact of prolonged GSK3β activation on regenerative functions of adult stem cells. Upon chronic inflammation, increased activation of GSK3β could result in a deregulation of the regenerative properties of adult stem cells (defect in tissue repair, tumor transformation). As sensors of the injured stem cell niche, adhesion and protease-activated receptors (Integrins, PARs) could play a crucial role in the sustained activation of GSK3β.
