Table 6.
Clinical trials with vitamin D in breast cancer.
| NCT Number | Status 1 | Start/Completion Date 1 | Stage | Title | References |
|---|---|---|---|---|---|
| NCT01169259 | Active, not recruiting | 07/2012–present | Phase III | Vitamin D and omega-3 trial (VITAL) | [118] |
| NCT00003787 | Completed | 03/1995–12/2018 | Not applicable | Women’s healthy eating and living study | [121,122] |
| NCT01948128 | Completed | 10/2013–09/2015 | Phase II | Effects of vitamin D in patients with breast cancer (OTT 12-06) | [123] |
| NCT00867217 | Completed | 03/2009–01/2011 | Phase II | Vitamin D3 for aromatase inhibitor-induced arthralgias (VITAL) | [128] |
| NCT01224678 | Completed | 10/2010–12/2014 | Phase III | Vitamin D and breast cancer biomarkers in female patients | NP |
| NCT01166763 | Completed | 05/2009–06/2011 | Not applicable | Modulation of breast cancer risk biomarkers by high dose vitamin D | NP |
| NCT04091178 | Completed | 10/2013–03/2017 | Phase II | Vitamin D supplementation to correct the vitamin D deficiency for breast cancer (OPTIVIT) | NP |
| NCT00976339 | Completed | 09/2007–12/2013 | Phase I | Study of vitamin D for premenopausal women at high risk for breast cancer | NP |
| NCT01472445 | Terminated | 11/2011–10/2015 | Phase II | Vitamin D and breast cancer: does weight make a difference? | NP |
| NCT01480869 | Completed | 07/2011–12/2014 | Phase III | Study of vitamin D supplementation tailored to vitamin D deficiency in breast cancer patients (VITACAL) | NP |
| NCT00656019 | Completed | 04/2018–12/2011 | Phase II | Development of vitamin D as a therapy for breast cancer | NP |
| NCT00859651 | Completed | 06/2009–04/2015 | Phase II | Vitamin D in postmenopausal women at high risk for breast cancer | NP |
| NCT01817231 | Completed | 05/2009–08/2009 | Not applicable | Epidemiological analysis of vitamin D and breast cancer risk in Saudi Arabian women | NP |
| NCT04166253 | Recruiting | 01/2020–present | Phase II | Protective role of vitamin D in breast cancer patients treated with doxorubicin (VDDOXO) | NP |
| NCT01965522 | Completed | 10/2013–05/2017 | Phase II | Antiproliferative effects of vitamin d and melatonin in breast cancer (MELO-D) | NP |
| NCT00944424 | Unknown | 07/2009–present | Phase III | Phase III trial of high dose vs. standard-dose vitamin D2 with docetaxel in metastatic breast cancer (GORG-002) | NP |
| NCT01988090 | Terminated | 12/2013–12/2018 | Phase II | High-dose vitamin D vs. standard-dose vitamin D study | NP |
| NCT02786875 | Recruiting | 11/2016–present | Phase III | Diet, exercise and vitamin D in breast cancer recurrence (DEDiCa) | NP |
| NCT01809171 | Terminated | 10/2013–08/2015 | Phase II | Placebo-controlled trial with vitamin D to prevent worsening/relieve aromatase inhibitor-induced musculoskeletal symptoms in breast cancer patients | NP |
| NCT02856503 | Withdrawn | Not applicable | Phase I/II | Effect of high dose vitamin D on cancer biomarkers and breast cancer tumors | NP |
| NCT00263185 | Completed | 11/2005–11/2009 | Phase I | High-dose vitamin D musculoskeletal symptoms and bone density in anastrozole-treated breast cancer with marginal vitamin D status | NP |
| NCT02186015 | Completed | 02/2015–11/2017 | Phase II | Safety, feasibility and efficacy of vitamin D supplementation in women with metastatic breast cancer (SAFE-D) | NP |
| NCT01608451 | Active, not recruiting | 09/2007–present | Phase III | Randomized controlled trial of neo-adjuvant progesterone and vitamin D3 in women with large operable breast cancer and locally advanced breast cancer | NP |
| NCT01425476 | Completed | 07/2008–11/2016 | Phase I/II | Changes in breast cancer biomarkers using synergistic prostaglandin inhibitors | NP |
| NCT00022087 | Completed | 12/2011–02/2009 | Phase III | Zoledronate, calcium, and vitamin D in preventing bone loss in women receiving adjuvant chemotherapy for breast cancer | NP |
| NCT01816555 | Terminated | 01/2013–11/2014 | Phase I | Vitamin D3 (Vit D3) supplementation and t cell immunomodulation in patients with newly diagnosed operative invasive ductal breast carcinoma | NP |
| NCT01747720 | Completed | 10/2012–05/2017 | Not applicable | Vitamin D and mammographic breast density (EVIDENSE) | NP |
| NCT00904423 | Terminated | 04/2009–04/2011 | Phase I/II | Ph I/II of vitamin D on bone mineral density and markers of bone resorption | NP |
| NCT03594214 | Not yet recruiting | 09/2018–present | Not applicable | Prognostic value of vitamin D levels in Egyptian females with breast cancer | NP |
| NCT01240213 | Completed | 10/2010–09/2012 | Not applicable | Vitamin D, diet and activity study (ViDA) | NP |
| NCT03986268 | Recruiting | 05/2019–present | Not applicable | Vitamin D can increase the pathological response of the breast cancer patients treated with neoadjuvant therapy | NP |
| NCT01769625 | Completed | 01/2009–11/2016 | Phase I/II | Changes in biomarkers using prostaglandin inhibitors | NP |
| NCT00926315 | Unknown | 06/2007–present | Not applicable | Gene expression profile of breast cancer samples after vitamin D supplementation | NP |
| NCT02936999 | Terminated | 08/2016–01/2019 | Not applicable | Vitamin D supplementation in women with DCIS and/or LCIS | NP |
| NCT00054418 | Completed | 03/2003–05/2008 | Phase III | Risedronate in preventing bone loss in premenopausal women receiving chemotherapy for primary breast cancer | NP |
| NCT00416715 | Completed | 10/2006–05/2010 | Phase II | Vitamin D deficiency, muscle pain, joint pain, and joint stiffness in postmenopausal women receiving letrozole for stage I-III breast cancer | NP |
| NCT01097278 | Completed | 11/2011–09/2017 | Not applicable | S0812 high dose cholecalciferol in premenopausal women at high-risk for breast cancer | NP |
| NCT01419730 | Completed | 08/2011–05/2020 | Phase II | Vitamin D and physical activity on bone health | NP |
| NCT00567606 | Completed | 04/2002–12/2007 | Phase IV | Prevention of osteoporosis in breast cancer survivors | NP |
1 Last access to ClinicalTrials.gov on 14 December 2020. NP—not published.