Figure 1.

Axon guidance cues and endo-lysosomal pathway in the axonal growth cone. A schematic picture depicts the modular structure of major axonal guidance cue-related receptors and their respective ligands. Classical interactions are represented by black arrows, while red arrows indicate crosstalk between different axon guidance families. In the bottom part of the figure, the endosomal–lysosomal compartment is shown to mediate both receptor recycling and degradation. (created with BioRender.com).