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. 2021 Jan 27;13(2):172. doi: 10.3390/pharmaceutics13020172

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Variations of the coefficients of correlation (R²) as a function of the excluded outliers and number of data points for: positive k_D: (A) LysSig2243 and (B) LysSig5161 and negative k_D: (C) LysSig2243+NaCl and (D) LysSig5161+NaCl. An increase of R² (based on the excluded outliers) is indicated by stacked green bars. The table contains the plate position, run, and plate number according to Figure 1; Figure 2; number of concentration steps (2, 5, 10, and 14-mg/mL or 2, 3.5, 5, 7, 8, 10, 12, and 14-mg/mL Lysozyme); used data points for the k_D analysis; and number of detected outliers by the Grubbs’ test. Corresponding k_D values are shown as blue spheres on the secondary y-axis. Error bars represent the deviation compared to the overall average k_D collected for all runs and plates.

Variations of the coefficients of correlation (R²) as a function of the excluded outliers and number of data points for: positive k_D: (A) LysSig2243 and (B) LysSig5161 and negative k_D: (C) LysSig2243+NaCl and (D) LysSig5161+NaCl. An increase of R² (based on the excluded outliers) is indicated by stacked green bars. The table contains the plate position, run, and plate number according to Figure 1; Figure 2; number of concentration steps (2, 5, 10, and 14-mg/mL or 2, 3.5, 5, 7, 8, 10, 12, and 14-mg/mL Lysozyme); used data points for the k_D analysis; and number of detected outliers by the Grubbs’ test. Corresponding k_D values are shown as blue spheres on the secondary y-axis. Error bars represent the deviation compared to the overall average k_D collected for all runs and plates.