Figure 10.
Statistical evaluation (inter-plate CV) with regards to (A) diffusion coefficients collected for three peptide-12 formulations in acetate buffer, pH 4.5, in the absence or presence of tonicity agents (w/o tonicity agent: dark orange, glycerol: orange, NaCl: slight orange) concentrations (in ascending order: 2, 4, 6, 8, and 10-mg/mL peptide-12); 5 replicates; and 3 runs. Significant differences are indicated by asterisks: *** p < 0.001. The plate design is shown in Appendix A, Figure A2. (B) The kD obtained from the D of 5 concentrations (2, 4, 6, 8, and 10-mg/mL peptide-12) and 5 replicates at 3 plate positions collected in 3 separate runs (9 total kD of each formulation).