Table 1.

Peptides inhibitors of MMP-2 and MMP-9 from marine source.

Compound	Source	Sequence	MMP-2	MMP-9	Model	Ref.
AOP	Haliotis discus hannai	Ala-Glu-Leu-Pro-Ser-Leu-Pro-Gly	Inhibition 2	Inhibition 2	HT1080 cells	[90]
AATP	Haliotis discus hannai	Lys-Val-Asp-Ala-Gln-Asp-Pro-Ser-Glu-Trp	Inhibition 2,3	Inhibition 2,3	HT1080 cells	[91]
ATPGDEG	Haliotis discus hannai	Ala-Thr-Pro-Gly-Asp-Glu-Gly	n.d.	Inhibition 1,2	HaCaT cells	[92]
BABP	Haliotis discus hannai	Glu-Met-Asp-Glu-Ala-Gln-Asp-Gly-Asp-Pro-Lys	Inhibition 2,3	Inhibition 2,3	HT1080 cells	[93]
LSGYGP	Tilapia fish skin gelatin hydrolysate	Leu-Ser-Gly-Tyr-Gly-Pro	n.d.	Inhibition 1,2	mice	[94]
Mere15	Meretrix meretrix Linnaeus	unknown	Inhibition 2,3	Inhibition 2,3	A549 cells	[95]

AOP: abalone oligopeptide; AATP: abalone anti-tumor peptide; ATPGDEG: Ala-Thr-Pro-Gly-Asp-Glu-Gly; BABP: boiled abalone byproduct peptide; LSGYGP: Leu-Ser-Gly-Tyr-Gly-Pro; Mere15: Mere Meretrix 15 kDa polypeptide. ¹ Inhibition of proteolytic activity (e.g., substrate degradation assays and molecular docking); ² inhibition of protein expression (e.g., in gel zymography, Western-blot, and ELISA); ³ inhibition of mRNA expression (e.g., reverse transcription polymerase chain reaction, RT-PCR). n.d.: not defined.