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. 2021 Jan 22;10(2):220. doi: 10.3390/cells10020220

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Due to the bell-shaped/biphasic pharmacological character of H₂S, pharmacological inhibitors of H₂S biosynthesis (via the removal of the stimulatory effects of endogenously produced, CBS, CSE or 3-MST-derived H₂S) as well as exogenous, pharmacological H₂S donor compounds (via stimulation of multiple cytostatic and cytotoxic mechanisms) can exert anticancer effects.