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. 2021 Jan 22;10(2):220. doi: 10.3390/cells10020220

Table 2.

Selected, H2S-activated enzymatic targets with potential relevance for cancer cell metabolism.

Target Effect Functional Consequence Reference
Glyceraldehyde-3-phosphate dehydrogenase
(GAPDH)
Activation via
sulfhydration
Stimulation of glycolysis [84]
Sirtuin 1, Sirtuin 3
(Sirt1, Sirt3)
Activation via
sulfhydration
Elevation of cellular NAD+ [85,86]
Lactate dehydrogenase A
(LDH-A)
Activation via
sulfhydration
Elevation of cellular NAD+ [60]
Protein phosphatase 2A
(PP2A)
Inhibition via
sulfhydration
Stimulation of AMP kinase [87]
ATP citrate lyase
(ACLY)
Upregulation via promoter activation Stimulation of acetyl-CoA synthesis [71]
Sulfide quinone oxidoreductase (SQR) Electron donation Stimulation of mitochondrial electron transport [66,88,89,90]
F0F1 ATP synthase
(Complex V)
Activation via
sulfhydration
Stimulation of ATP synthesis [91,92]
Mitochondrial cAMP phosphodiesterase
(PDE2A)
Inhibition via sulfhydration and dimerization Increased mitochondrial cAMP content, stimulation of mitochondrial ATP synthesis [93]
Mitofusin 2
(MFN2)
Upregulation through inhibition of its proteosomal degradation Stimulation of mitochondrial biogenesis [94]
Dynamin 1 like protein
(Drp1)
Upregulation via ERK1/2 Stimulation of mitochondrial biogenesis [95]
Reactive oxygen
and reactive nitrogen species
(ROS, RNS)
Neutralization of ROS/RNS via direct interactions and via upregulation of antioxidant systems through NRF2 activation and p66Shc sulfhydration Protection against mitochondrial oxidative stress [19,96,97,98,99,100]
DJ-1 Sulfhydration, which prevents its oxidative inactivation Maintenance of mitochondrial redox balance [45]