Table 6.
Human I-type lectins, their carbohydrate ligands and protein expression in the organs.
|
Common Name (HUGO Name if Different) |
Gene Symbol | Carbohydrate Preferential Affinity | Protein Expression in the Organs |
|---|---|---|---|
| Siglecl1 (Sialic acid binding Ig like lectin 1) | SIGLEC1 | α-(2-3)-Sialic acid, α-(2-6)-Sialic acid, α-(2-8)-Sialic acid [94] | Bone marrow, lung |
| Siglec2 (CD22 molecule) a) | CD22 | α-(2-6)-Sialic acid [95,96] | Appendix, lymph node, spleen, tonsil |
| Siglec3 (CD33 molecule) | CD33 | α-(2-6)-Sialic acid, α-(2-3)-Sialic acid [97] | Appendix, bone marrow, lung, lymph node, skin, spleen, tonsil |
| Siglec4a, MAG (Myelin associated glycoprotein) | MAG | α-(2-3)-Sialic acid [98] | Brain |
| Siglec5 (Sialic acid binding Ig like lectin 5) | SIGLEC5 | α-(2-3)-Sialic acid, α-(2-6)-Sialic acid, α-(2-8)-Sialic acid [99] | Bone marrow, lymph node, placenta, spleen, tonsil |
| Siglec6 (Sialic acid binding Ig like lectin 6) | SIGLEC6 | Sialic acid-α-(2-6)-N-acetylgalactosamine (Sialyl-Tn) [100] | Placenta |
| Siglec7 | SIGLEC7 | α-(2-6)-Sialic acid, α-(2-8)-Sialic acid, α-(2-3)-Sialic acid [101] and disialogangliosides [102,103,104] | b) |
| Siglec8 | SIGLEC8 | α-(2-3)-Sialic acid, α-(2-6)-Sialic acid [105] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Siglec9 (Sialic acid binding Ig like lectin 9) | SIGLEC9 | α-(2-3)-Sialic acid, Sialyl Lewis x, α-(2-6)-Sialic acid, α-(2-8)-Sialic acid [106] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Siglec10 (Sialic acid binding Ig like lectin 10) | SIGLEC10 | α-(2-3)-Sialic acid, α-(2-6)-Sialic acid [107] | Appendix, bone marrow, lymph node, soft tissue, spleen, tonsil |
| Siglec11 (Sialic acid binding Ig like lectin 11) | SIGLEC11 | α-(2-8)-Sialic acid [101] | b) |
| Siglec14 (Sialic acid binding Ig like lectin 14) | SIGLEC14 | Sialic acid- α-(2-6)-N-acetylgalactosamine (Sialyl-Tn), N-acetylneuraminic acid [108] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Siglec15 (Sialic acid binding Ig like lectin 15) | SIGLEC15 | Sialyl-Tn [109] | b) |
| CD2 molecule a) | CD2 | N-glycans with fucose [110] | Appendix, lymph node, spleen, tonsil |
| CD83 molecule | CD83 | Sialic acid [111] | Appendix, bone marrow, lung, lymph node, spleen, tonsil |
| Intercellular adhesion molecule 1 | ICAM1 | Hyaluronan [112] | Appendix, bone marrow, brain, endometrium, fallopian tube, kidney, lung, lymph node, spleen, testis, tonsil |
| L1 cell adhesion molecule | L1CAM | α-(2-3)-Sialic acid [113] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, proximal digestive tract, skin |
| Myelin protein zero | MPZ | SO4– –3GlucA-β-(1-3)-Gal-β-(1–4)-GlcNAc (HNK-1 antigen) [101] | Bronchus, esophagus, fallopian tube, small intestine, soft tissue, stomach, testis |
| Neural cell adhesion molecule 1 | NCAM1 | High N-linked d-mannose [114] | Brain, colon, hearth muscle, pancreas, smooth muscle, soft tissue, thyroid gland |
| Neural cell adhesion molecule 2 | NCAM2 | c) | Brain, bronchus, colon, duodenum, gallbladder, ovary, rectum, small intestine, soft tissue, testis |