Table 7.
Human L-type lectins, their carbohydrate ligands and protein expression in the organs.
|
Common Name (HUGO Name if Different) |
Gene Symbol | Carbohydrate Preferential Affinity | Protein Expression in the Organs |
|---|---|---|---|
| Calnexin | CANX | Non-reducing glucose residues in an oligosaccharide (Glc(Man)9(GlcNAc)2) [118] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Calreticulin | CALR | Non-reducing glucose residues in an oligosaccharide (Glc(Man)9(GlcNAc)2) [119] | Bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, pancreas, skin |
| Calreticulin 3 | CALR3 | a) | Testis |
| Lectin, mannose-binding 1 | LMAN1 | α-(1-2) mannans with free OH-3, OH-4 and OH-6 [120] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Lectin, mannose-binding 1 like | LMAN1L | a) | b) |
| Lectin, mannose-binding 2 | LMAN2 | High α-(1-2) mannans, Low affinity for d-glucose and N-acetylglucosamine [121] | Bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, pancreas |
| Lectin, mannose-binding 2 like | LMAN2L | α-(1-2) trimannose [122] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Adhesion G protein-coupled receptor D1 | ADGRD1 | a) | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Adhesion G protein-coupled receptor D2 | ADGRD2 | a) | b) |
| Amyloid P component, serum | APCS | Heparin, dextran sulfate proteoglycans [123] | b) |
| C-reactive protein | CRP | Galactose 6-phosphate, Gal-β-(1-3)-GalNAc, Gal-β-(1-4)-GalNAc, Gal-β-(1-4)-Gal-β-(1-4)-GlcNAc, other phosphate-containing ligands [124,125] | Liver, gallbladder, soft tissue |
| Neuronal pentraxin 1 | NPTX1 | a) | Brain, testis |
| Neuronal pentraxin 2 | NPTX2 | a) | Adrenal gland, brain, pancreas, pituitary gland, testis |
| Neuronal pentraxin receptor | NPTXR | a) | Brain |
| Pentraxin 3 | PTX3 | Heparin [126] | b) |
| Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | SVEP1 | a) | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas |