Table 10.
Human R-type lectins, their carbohydrate ligands and protein expression in the organs.
|
Common Name (HUGO Name if Different) |
Gene Symbol | Carbohydrate Preferential Affinity | Protein Expression in the Organs |
|---|---|---|---|
| Polypeptide N-acetylgalactosaminyltransferase 1 | GALNT1 | GalNAc [136] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Polypeptide N-acetylgalactosaminyltransferase 2 | GALNT2 | GalNAc [136,137] | Bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Polypeptide N-acetylgalactosaminyltransferase 3 | GALNT3 | GalNAc [136] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Polypeptide N-acetylgalactosaminyltransferase 4 | GALNT4 | GalNAc, GalNAc-glycosylated substrates [136,138] | a) |
| Polypeptide N-acetylgalactosaminyltransferase 5 | GALNT5 | GalNAc [136] | Appendix, bronchus, cervix (uterine), colon, duodenum, esophagus, gallbladder, lung, oral mucosa, rectum, salivary gland, small intestine, stomach, tonsil, vagina |
| Polypeptide N-acetylgalactosaminyltransferase 6 | GALNT6 | GalNAc [136] | Bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Polypeptide N-acetylgalactosaminyltransferase 7 | GALNT7 | GalNAc, GalNAc-glycosylated substrates [100] | Bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract |
| Polypeptide N-acetylgalactosaminyltransferase 8 b) | GALNT8 | GalNAc [139] | Bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, skin |
| Polypeptide N-acetylgalactosaminyltransferase 9 | GALNT9 | GalNAc [140] | a) |
| Polypeptide N-acetylgalactosaminyltransferase 10 | GALNT10 | GalNAc [141] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Polypeptide N-acetylgalactosaminyltransferase 11 | GALNT11 | GalNAc [142] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Polypeptide N-acetylgalactosaminyltransferase 12 | GALNT12 | GalNAc [143] | Appendix, bone marrow, brain, breast, cervix (uterine), endometrium, fallopian tube, prostate, soft tissue, thyroid gland, tonsil, skin |
| Polypeptide N-acetylgalactosaminyltransferase 13 | GALNT13 | GalNAc [144] | Adrenal gland, lung, salivary gland |
| Polypeptide N-acetylgalactosaminyltransferase 14 | GALNT14 | GalNAc [145] | a) |
| Polypeptide N-acetylgalactosaminyltransferase 15 | GALNT15 | GalNAc [146] | a) |
| Polypeptide N-acetylgalactosaminyltransferase 16 | GALNT16 | GalNAc [147] | Bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Polypeptide N-acetylgalactosaminyltransferase 17 | GALNT17 | GalNAc [148] | Brain |
| Polypeptide N-acetylgalactosaminyltransferase 18 | GALNT18 | GalNAc [149] | Adipose and soft tissue, bone marrow and lymphoid tissues, brain, endocrine tissues, female tissues, gastrointestinal tract, kidney and urinary bladder, lung, male tissues, muscle tissues, pancreas, proximal digestive tract, skin |
| Polypeptide N-acetylgalactosaminyltransferase like 5 | GALNTL5 | c) [150] | Testis |