Table 3.
The degradation constant K, t90 and R2 of two tacrolimus eye drops (TBS 40 and TLI 40) obtained by interpolation of the calculated regression line (% of remaining tacrolimus concentration vs time).
| Formulations | Storage Condition | K (days−1) | t90 (days) | R2 | |||
|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | ||
| TBS 40 | Refrigeration (4 °C) | 0.0006 | 4.3 × 10−5 | 184.32 | 13.5 | 0.8890 | 0.0179 |
| Room temperature (25 °C) | 0.0067 | 0.0002 | 15.72 | 0.53 | 0.9645 | 0.0057 | |
| Oven temperature (40 °C) | 0.0713 | 0.0016 | 1.48 | 0.03 | 0.9966 | 0.0012 | |
| TLI 40 | Refrigeration (4 °C) | 0.0011 | 5.8 × 10−5 | 98.50 | 5.2 | 0.9410 | 0.040 |
| Room temperature (25 °C) | 0.0067 | 0.0002 | 15.66 | 0.40 | 0.9867 | 0.0035 | |
| Oven temperature (40 °C) | 0.0577 | 0.0004 | 1.82 | 0.01 | 0.9959 | 0.0007 | |