Table 2.

Upregulated pathways in vividly growing cancer spheres.

Pathway	p-Value (RNAseq from Vividly Growing Cancer Spheres)
Hs_Integrated_Cancer_Pathway_WP1971_82939	1.02 × 104
Hs_Intrinsic_Pathway_for_Apoptosis_WP1841_83332	0.002799811
Hs_Signaling_by_Retinoic_Acid_WP3323_83286	0.003082763
Hs_Vitamin_A_and_Carotenoid_Metabolism_WP716_83589	0.003229062
Hs_BMAL1-CLOCK, NPAS2_activates_circadian_gene_expression_WP3355_83343	0.003687094
Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941	0.004416806
Hs_Pre-NOTCH_Expression_and_Processing_WP2786_83418	0.004513508
Hs_Lipid_storage_and_perilipins_in_skeletal_muscle_WP2887_85092	0.011662396
Hs_Uptake_and_function_of_anthrax_toxins_WP3390_83389	0.013593029
Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694	0.013785134

Pathways were explicitly upregulated in vividly growing cancer spheres, irrespective of continuous RAB39A repression. Note: The pathway of retinoic acid signaling, namely vitamin A and carotenoid metabolism, is listed in the superior order of the top 10 rankings.