Figure 1.

Natural products targeting arginase. Compounds derived from multiple structural classes have been developed as anti-leishmanial agents in drug development including (a) flavonols, (b) flavanols that give rise to various derivatives based on stereochemistry (c), gallic acid, (d) cinnamic acid-based analogs, and (e) piperidine alkaloids. Abbreviations: catechin (C); epicatechin (EC); catechin gallate (GC); epicatechin gallate (ECG); gallocatechin gallate (GCG); epigallocatechin-3-gallate (EGCG).