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Cells were plated onto the apical side of Matrigel-coated filters in the presence and absence of either SD-Sr-ICOS-Fc, SG-Sr-ICOS-Fc, SD-Sr, and SG-Sr. ICOS-Fc was used as positive control. FBS 20% was loaded in the basolateral chamber as a chemotactic stimulus. Data are expressed as mean± SEM (n = 5) of the percentage of migration versus control migration (FBS 20%). * p < 0.05; ** p < 0.01 SG-Sr-ICOS-Fc vs. SG-Sr and SD-Sr-ICOS-Fc vs. SD-Sr.
