Table 3.
Univariable and multivariable Cox regression models for overall survival: Effects of nutritional and other variables.
| Variable | Univariable Models | Multivariable Model 1 (61 Deaths in 137 Patients) |
Multivariable Model 2 (63 Deaths in 138 Patients) |
||||
|---|---|---|---|---|---|---|---|
| Deaths/N | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
| Servings of 1–3/week or more vs. <1/week or never | |||||||
| Salads | 61/137 | 0.45 (0.26, 0.77) | 0.003 | 0.64 (0.35, 1.16) | 0.141 | -- | |
| In P16− | 23/45 | 0.67 (0.27, 1.66) | 0.381 | -- | -- | ||
| In P16+ | 7/27 | 0.25 (0.05, 1.12) | 0.069 | -- | -- | ||
| In p16 = NA | 31/65 | 0.43 (0.20, 0.89) | 0.024 | -- | -- | ||
| Other Vegetables | 61/137 | 0.66 (0.35, 1.24) | 0.194 | -- | -- | ||
|
Salads or Other
Vegetables |
63/138 | 0.40 (0.20, 0.81) | 0.011 | -- | 0.40 (0.17, 0.91) | 0.029 | |
| Potatoes | 60/136 | 1.31 (0.6, 2.89) | 0.501 | -- | -- | ||
| Carrots | 61/135 | 0.83 (0.5, 1.38) | 0.480 | -- | -- | ||
| Fruits | 65/142 | 0.98 (0.55, 1.75) | 0.956 | -- | -- | ||
| Juices | 63/137 | 1.28 (0.71, 2.32) | 0.417 | -- | -- | ||
| HPV status: P16− vs. P16+ | 71/149 | 1.85 (0.89, 3.86) | 0.099 | 1.71 (0.64, 4.59) | 0.289 | 1.89 (0.70, 5.16) | 0.212 |
| NA vs. P16+ | 1.77 (0.88, 3.58) | 0.109 | 3.70 (1.41, 9.70) | 0.008 | 4.48 (1.71, 11.72) | 0.002 | |
| T stage: T3-T4 vs. T1-T2 | 71/149 | 2.55 (1.52, 4.29) | <0.001 | 1.85 (0.93, 3.67) | 0.081 | 1.68 (0.84, 3.37) | 0.145 |
| solCD44 ≥8.1 vs. <8.1 * | 71/149 | 5.48 (3.14, 9.55) | <0.0001 | 3.17 (1.43, 7.03) | 0.004 | 3.12 (1.45, 6.69) | 0.004 |
| Protein ≥1.05 vs. < 1.05 * | 71/149 | 2.79 (1.74, 4.47) | <0.0001 | 1.36 (0.72, 2.60) | 0.347 | 1.61 (0.84, 3.10) | 0.151 |
| Age: ≥60 vs. <60 years-old | 71/149 | 2.18 (1.36, 3.50) | 0.001 | 2.15 (1.15, 4.03) | 0.017 | 2.14 (1.15, 3.97) | 0.016 |
| Race: Black vs. non-Black | 71/149 | 2.97 (1.74, 5.05) | <0.0001 | 1.62 (0.77, 3.44) | 0.205 | 1.68 (0.78, 3.61) | 0.188 |
| Ethnicity: Non-Hispanic vs. Hispanic | 71/149 | 1.88 (1.17, 3.02) | 0.009 | 3.04 (1.51, 6.10) | 0.002 | 2.54 (1.28, 5.01) | 0.007 |
| Gender: Female vs. Male | 71/149 | 1.22 (0.70, 2.14) | 0.477 | 1.55 (0.77, 3.13) | 0.221 | 1.65 (0.82, 3.35) | 0.163 |
| Drinking Habits: Mod/Heavy vs. Mild/Non-Drinker | 71/149 | 1.72 (1.08, 2.75) | 0.023 | 0.85 (0.39, 1.84) | 0.675 | 1.25 (0.58, 2.67) | 0.566 |
| Smoking History: Ever vs. Never | 71/149 | 1.64 (0.86, 3.13) | 0.130 | 2.04 (1.06, 3.92) | 0.032 | 1.87 (0.99, 3.54) | 0.053 |
| SES: Low vs. High | 71/149 | 1.54 (0.92, 2.58) | 0.104 | 1.94 (0.81, 4.64) | 0.135 | 1.60 (0.68, 3.78) | 0.286 |
| Oral heath score: poor/fair/missing vs. good. | 71/149 | 1.89 (1.07, 3.35) | 0.028 | 1.31 (0.63, 2.75) | 0.470 | 1.48 (0.73, 2.99) | 0.279 |
|
Teeth removed: 6 or more/All/missing vs. 5 or less |
71/149 | 1.45 (0.91, 2.32) | 0.117 | 0.97 (0.49, 1.90) | 0.925 | 0.95 (0.47, 1.90) | 0.884 |
|
Gargle: Poor/Fair/Missing vs. Good |
71/149 | 2.45 (1.53, 3.92) | <0.001 | 1.35 (0.72, 2.53) | 0.355 | 1.25 (0.68, 2.31) | 0.476 |
P16 = NA: not available HPV status. HR: hazard ratio. P: p value from Wald test for H0: HR = 1 (same risk in both groups). Bold indicates results statistically significant at p < 0.05. * Cutpoints were determined using SAS macro %FINDCUT, based on minimum Wald test p value, searching the CD44 range 1.5 to 11 by 0.1 and protein range 0.5 to 1.7 by 0.05. Multivariable model 1 provides the adjusted effect of salad intake and multivariable model 2 provides the adjusted effect of salad/other vegetables intake on overall survival, with adjustment for HPV status, T-stage, solCD44, protein, age, race, ethnicity, gender, smoking history, drinking habits, SES, oral heath score, teeth removed, and gargle. Thus, -- indicates a variable not included in the model.