Figure 1.

Schematic and simplified overview of the effects that chemokine-chemokine receptor axis have on leukocyte recruitment. Various chemokines and chemokine receptors are visualized that play a role in leukocyte recruitment. Activated endothelial cells secrete a wide variety of chemokines that attract leukocytes like monocytes and neutrophils towards the vessel wall in a process called chemotaxis, followed by tethering, rolling and transmigration. Furthermore, activated macrophages secrete chemokines that stimulate this leukocyte recruitment process and it has been shown that chemokine receptors influence endothelial permeability, which is an important aspect for leukocyte transmigration (Created with Biorender.com).