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. Author manuscript; available in PMC: 2022 Feb 2.
Published in final edited form as: Circulation. 2020 Nov 9;143(5):410–423. doi: 10.1161/CIRCULATIONAHA.120.051775

Figure 3. Meta-analysis of associations between premature menopause and CHIP in the UK Biobank and Women’s Health Initiative.

Figure 3.

Premature menopause was independently associated with CHIP. Associations were larger for natural premature menopause but smaller and non-significant for surgical premature menopause. Models for both cohorts are adjusted for age, the first 10 principal components of ancestry, ever-smoking, diabetes mellitus, and use of hormone therapy. WHI models are further adjusted for race/ethnicity, enrollment in the WHI observational study vs. clinical trial, and whether women were randomized to hormone therapy vs. placebo. WHI = Women’s Health Initiative; CHIP = clonal hematopoiesis of indeterminate potential; VAF = variant allele frequency.