Table 5.
Correlations between PARP1 expression and histopathological parameters of primary tumors in cutaneous melanoma patients without lymph node metastases.
| Histopathological Parameters | PARP1 Expression | ||
|---|---|---|---|
| Low (H-Score ≤ 280) (n = 72) |
High (H-Score > 280) (n = 24) |
p Value | |
| Breslow thickness a | 0.0030 | ||
| ≤1 mm | 26 (36%) | 2 (8%) | |
| 1.01–2.00 mm | 15 (21%) | 5 (21%) | |
| 2.01–4.00 mm | 20 (28%) | 5 (21%) | |
| >4 mm | 11 (15%) | 12 (50%) | |
| Clark level a | 0.13 | ||
| I | 0 (0%) | 0 (0%) | |
| II | 30 (42%) | 4 (17%) | |
| III | 22 (31%) | 10 (42%) | |
| IV | 16 (22%) | 8 (33%) | |
| V | 4 (6%) | 2 (8%) | |
| Histological type b | 0.16 | ||
| Superficial spreading melanoma | 43 (60%) | 10 (42%) | |
| Nodular melanoma | 29 (40%) | 14 (58%) | |
| Acral lentiginous melanoma | 0 (0%) | 0 (0%) | |
| Mitotic rate a | 0.00071 | ||
| 0 | 30 (42%) | 1 (4%) | |
| 1–3 | 17 (24%) | 7 (29%) | |
| ≥4 | 25 (35%) | 16 (67%) | |
| Ulceration c | 0.023 | ||
| No | 53 (74%) | 11 (46%) | |
| Yes | 19 (26%) | 13 (54%) | |
| Lymphangioinvasion c | 1.0 | ||
| No | 70 (97%) | 24 (100%) | |
| Yes | 2 (3%) | 0 (0%) | |
| Tumor-infiltrating lymphocytes c | 0.26 | ||
| No | 4 (6%) | 1 (4%) | |
| Non-brisk | 37 (51%) | 17 (71%) | |
| Brisk | 31 (43%) | 6 (25%) | |
| Microsatellitosis c | 1.0 | ||
| No | 72 (100%) | 24 (100%) | |
| Yes | 0 (0%) | 0 (0%) | |
| Regression c | 0.15 | ||
| No | 71 (99%) | 22 (96%) | |
| Yes | 1 (1%) | 1 (4%) | |
ap of Wilcoxon two-sample test. b p value of Fisher’s exact test. c p value of chi2 test. Statistically significant results (p < 0.05) are presented in bold.