Table 3.
The effects of different concentrations of excipients in SNEDDS formulations on self-emulsification efficiency, particle size, and size distribution (PdI) of the obtained nanoemulsions.
| Formulations * | Self-Emulsification Efficiency | Particle Size ** (nm) |
PdI ** |
|---|---|---|---|
| F1 | C | 317.24 ± 1.34 g,h | 0.27 ± 0.08 d,e |
| F2 | D | 178.40 ± 0.42 f | 0.20 ± 0.03 c,d |
| F3 | B | 158.50 ± 1.57 e,f | 0.24 ± 0.13 c,d |
| F4 | A | 40.42 ± 0.76 a | 0.12 ± 0.02 a,b |
| F5 | D | 255.00 ± 0.99 g | 0.59 ± 0.00 f |
| F6 | C | 347.40 ± 4.34 h | 0.18 ± 0.09 a,b,c,d |
| F7 | A | 65.82 ± 0.22 a,b | 0.22 ± 0.01 b |
| F8 | B | 490.80 ± 21.43 i | 0.09 ± 0.05 a |
| F9 | A | 52.57 ± 1.35 a | 0.14 ± 0.01 a,b |
| F10 | B | 136.07 ± 7.84 e | 0.38 ± 0.06 f |
| F11 | A | 28.28 ± 0.36 a | 0.11 ± 0.02 a |
| F12 | C | 329.90 ± 9.28 h | 0.14 ± 0.03 a,b,c |
| F13 | B | 115.53 ± 1.62 c | 0.37 ± 0.01 e,f |
| F14 | A | 98.98 ± 1.62 c | 0.15 ± 0.00 a,b,c |
* Visually all systems were homogenous and did not show any phase separation. ** Lowercase letters indicate significant differences (p < 0.05) for the particle size and PdI analysis of the different formulations.