Figure 3.

Effects of DK-I-56-1 (DK) on Tourette Syndrome-related motoric responses in D1CT-7 mice exposed to spatial confinement. DK significantly reduced (A) tic-like responses (F(2,15) = 9.66, p = 0.002) and the duration of (B) grooming behavior (F(2,19) = 4.48; p = 0.03), but not (C) digging or (D) rearing. All analyses were performed by one-way ANOVAs. Significance refers to the results of post-hoc comparisons. * p < 0.05; *** p < 0.001 in comparison with vehicle (VEH). n = 6–8/group. Doses are indicated in mg/kg (IP). For further details, see text.