Figure 5.

Effects of DK-I-56-1 (DK, 10 mg/kg, IP) on tic-like responses in D1CT-7 and wild-type (WT) mice exposed to spatial confinement, as compared with dopaminergic antagonists. (A) DK significantly reduced tic-like behaviors in both genotypes (Genotype × treatment interaction: F(1,25) = 4.46; p = 0.04). (B) The D₁ receptor antagonist SCH 23390 (SCH, 0.5 mg/kg, IP) also reduced tic-like behaviors in all genotypes (Genotype × treatment interaction: F(1,32) = 11.54; p = 0.002). (C) The D₂ receptor antagonist haloperidol had similar effects (HAL, 0.5 mg/kg, IP) (Genotype × treatment interaction: F(1,30) = 4.61, p = 0.04). All analyses were performed by two-way ANOVAs. * p < 0.05; *** p < 0.001; **** p < 0.0001 vs. WT mice treated with vehicle (VEH); ^# p < 0.05; ^#### p < 0.0001 vs. D1CT-7 mice treated with VEH. n = 7–9/experimental group. For further details, see text.