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. 2021 Jan 28;11(2):175. doi: 10.3390/biom11020175

Figure 6.

Figure 6

Effects of DK-I-56-1 (DK, 10 mg/kg, IP) and dopaminergic antagonists on tic-like responses in D1CT-7 and wild-type (WT) mice exposed to spatial confinement. (A) D1CT-7 mice had lower startle amplitude than WT littermates (Main effect of genotype: F(1,25) = 49.04, p < 0.0001), but this difference was not affected by DK. (B) DK reversed the PPI deficits observed in D1CT-7 mice, but not WT mice (Genotype × treatment interaction: F(1,25) = 12.37; p = 0.002). (C) The D1 receptor antagonist SCH 23390 (0.5 mg/kg, IP) did not affect startle amplitude. (D) SCH 23390 reversed the PPI deficits in D1CT-7 mice (Genotype × treatment interaction: F(1,24) = 5.36; p = 0.03). (E) The D2 receptor antagonist haloperidol (HAL, 0.5 mg/kg, IP) reduced startle reflex in both WT and D1CT-7 mice (Main effect of treatment: F(1,24) = 36.64, p < 0.0001). (F) HAL reversed the PPI deficits observed in D1CT-7 mice (Genotype × treatment interaction: F(1,24) = 44.99; p < 0.0001). ^^^^ p < 0.0001; main effect of genotype (D1CT-7 vs. WT); ** p < 0.01; **** p < 0.0001 vs. WT mice treated with vehicle (VEH); #### p < 0.0001 vs. D1CT-7 group vehicle-treated. n = 7–8/group. For further details, see text.