Figure 8.

Effects of DK-I-56-1 (DK, 10 mg/kg, IP) on (A) startle response and (B) prepulse inhibition (PPI) in C57/BL6 mice treated with SKF 82958 (0.5 mg/kg, IP). Two-way ANOVA detected that SKF 82958 dramatically reduced PPI (Main effect: F(1,42) = 9.73, p = 0.003), and DK countered the PPI deficits caused by the D₁ receptor agonist (Interaction: F(1,42) = 5.43, p = 0.02). Significance levels refer to the results of post-hoc comparisons. ** p < 0.01 vs. mice treated with the vehicle of DK (VEH) and saline (SAL, controlling for SKF 82958); ^### p = 0.0001 vs. mice treated with VEH and SKF 82958. n= 11–12/group. For further details, see text.