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. 2021 Jan 28;11(2):175. doi: 10.3390/biom11020175

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DK-I-56-1 (DK, 10 nmol) infusion in the medial prefrontal cortex (mPFC) (A) failed to affect startle reflex in mice, but (B) significantly countered the PPI deficits produced by SKF 82958 (F(1,20) = 19.34; p = 0.0003). Conversely, infusions of this drug in the nucleus accumbens (NAc) (C) did not affect startle amplitude, and (D) failed to reverse the PPI deficits induced by SKF 82958. All analyses were performed by 2-way ANOVAs. Significance levels refer to the results of post-hoc comparisons. * p < 0.05; **** p < 0.0001 vs. mice treated with the vehicle of DK (VEH) and saline (SAL, controlling for SKF 82958); ^### p = 0.0001 vs. mice treated with VEH and SKF 82958. n = 6–8/group. For further details, see text.