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. 2021 Jan 25;12(2):159. doi: 10.3390/genes12020159

Figure 4.

Figure 4

Mutation dot plot of 30 genes with 52 of the most clinically significant mutations. We selected mutations with only High impact or pathogenic mutations in ClinVar for the mutation dot plot. Mutations of the parent cells that remained in the resistant cells are colored blue, while newly exhibited mutations in the resistant cells are colored red. The bar graph represents the number of mutations in each cell. T47D-PR cells obtained the following new mutations: MUC16 (K13558fs), NCOR1 (R190*), and RB1 (Y659fs). Meanwhile, MCF7-PR cells exhibited the following new mutations: MUC4 (M3855fs, L3857fs, T3860fs, P3862fs) and RSPO2 (R64*).