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. 2021 Jan 30;9(2):287. doi: 10.3390/microorganisms9020287

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histopathology (Gram staining) of skin lesions shows that USA300 infections have a higher bacterial load. Representative images (40× magnification) from various layers of skin and subcuticular tissue in the lesion from M92, USA400-CMRSA7, and USA300-C2406 infections on day 4 are presented. USA300-C2406 infections have a higher bacterial load as compared to USA400-CMRSA7 and M92 infections. Positive spots (bacteria) are labeled with a black box or arrow. The relative quantity of positive spots is indicated with + (positive), ++, and – (negative for bacteria).