Table 1.
Patient clinical characteristics and IOTA Simple Rules results (n = 479).
| Parameters | Malignant (n = 145) | Benign (n = 334) | p-Value | ||
|---|---|---|---|---|---|
| n | (%) | n | (%) | ||
| Clinical characteristics | |||||
| Age (year) * | 45.4 | ±14.8 | 40.6 | ±11.0 | <0.001 |
| Nulliparity | 75 | (51.7) | 137 | (41.0) | 0.035 |
| Post-menopause | 58 | (40.0) | 57 | (17.1) | <0.001 |
| Biomarker | |||||
| Serum CA-125, (U/mL) ** | 405.8 | (122.4, 714.8) | 39.0 | (23.6, 56.9) | <0.001 |
| Range (min-max) | (13.7–2023.6) | (5.4–278.3) | |||
| IOTA Simple Rules features | |||||
| Malignant tumor (M-features) | |||||
| M1 | 73 | (50.3) | 16 | (4.8) | <0.001 |
| M2 | 34 | (23.5) | 11 | (3.3) | <0.001 |
| M3 | 32 | (22.1) | 26 | (7.8) | <0.001 |
| M4 | 74 | (51.0) | 26 | (7.8) | <0.001 |
| M5 | 96 | (66.2) | 35 | (10.5) | <0.001 |
| Benign tumor (B-features) | |||||
| B1 | 9 | (6.2) | 169 | (50.6) | <0.001 |
| B2 | 1 | (0.7) | 17 | (5.1) | 0.018 |
| B3 | 5 | (3.5) | 66 | (19.8) | <0.001 |
| B4 | 17 | (11.7) | 78 | (23.4) | 0.004 |
| B5 | 42 | (29.0) | 297 | (88.9) | <0.001 |
| IOTA Simple Rules diagnosis | |||||
| Benign | 19 | (13.1) | 253 | (75.8) | NA |
| Malignant | 98 | (67.6) | 22 | (6.6) | NA |
| Inconclusive | 28 | (19.3) | 59 | (17.6) | 0.699 |
Abbreviations: IOTA, International Ovarian Tumor Analysis; SD, standard deviation; IQR, interquartile range; NA, not applicable. * Mean ± SD ** Median (IQR).