Table 2.
Evaluation of the diagnostic value of serum CA-125 to the IOTA Simple Rules for premenopausal and postmenopausal women.
| Models | Predictors Included | ß | (95%CI) | p-Value | AuROC (95%CI) |
|---|---|---|---|---|---|
| Premenopausal women (n = 364) | |||||
| PRE1 | IOTA Simple Rules | ||||
| Benign | Ref | Ref | 0.89 (0.86, 0.93) | ||
| Inconclusive | 2.72 | (1.77, 3.68) | <0.001 | ||
| Malignant | 4.68 | (3.72, 5.64) | <0.001 | ||
| PRE2 | Log serum CA-125 (FP1) § | 0.02 | (0.01, 0.03) | <0.001 | 0.88 (0.83, 0.93) |
| PRE3 | IOTA Simple Rules | ||||
| Benign | Ref | Ref | 0.94 (0.91, 0.98) | ||
| Inconclusive | 2.10 | (0.99, 3.21) | <0.001 | ||
| Malignant | 4.27 | (3.11, 5.42) | <0.001 | ||
| Log serum CA-125 (FP1) § | 0.02 | (0.01, 0.03) | <0.001 | ||
| Intercept (constant) | −4.01 | (−4.95,−3.06) | <0.001 | ||
| Postmenopausal women (n = 115) | |||||
| POST1 | IOTA Simple Rules | ||||
| Benign | Ref | Ref | 0.83 (0.76, 0.90) | ||
| Inconclusive | 0.84 | (−0.37, 2.04) | 0.173 | ||
| Malignant | 3.81 | (2.48, 5.13) | <0.001 | ||
| POST2 | Log serum CA-125 (FP1) † | 0.02 | (0.01, 0.03) | <0.001 | 0.88 (0.81, 0.95) |
| POST3 | IOTA Simple Rules | ||||
| Benign | Ref | Ref | 0.98 (0.95, 1.00) | ||
| Inconclusive | 0.71 | (−1.63, 3.05) | 0.551 | ||
| Malignant | 5.30 | (3.17, 7.43) | <0.001 | ||
| Log serum CA-125 (FP1) † | 0.03 | (0.01, 0.04) | <0.001 | ||
| Intercept (constant) | −2.23 | (−3.52,−0.93) | |||
Abbreviations: ß, beta-coefficient of logistic regression; IOTA, International Ovarian Tumor Analysis; Ref, reference; FP1, first-degree fractional polynomial; CI, confidence interval; AuROC, area under the receiver operating characteristic curve. § a re-centered FP1 term for premenopausal model: log (CA-125)3−72.7142 † a re-centered FP1 term for postmenopausal model: log (CA-125)3−97.7399.