Table 4.
Diagnostic indices of the combined IOTA Simple Rules models for premenopausal women.
| Malignant | Benign | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | |
|---|---|---|---|---|---|---|---|
| n | n | (95%CI) | (95%CI) | (95%CI) | (95%CI) | (95%CI) | |
| Premenopausal women (n = 364) | |||||||
| IOTA SR–refer women with inconclusive results | |||||||
| Malignant and inconclusive | 81 | 69 | 93.1 | 75.1 | 54.0 | 97.2 | 3.74 |
| Benign | 6 | 208 | (85.6, 97.4) | (69.6, 80.1) | (45.7, 62.2) | (94.0, 99.0) | (3.02, 4.62) |
| IOTA SR X CA-125 for premenopausal women | |||||||
| Predicted risk ≥10% | 80 | 59 | 92.0 | 78.7 | 57.6 | 96.9 | 4.32 |
| 7 | 218 | (84.1, 96.7) | (73.4, 83.4) | (48.9, 65.9) | (93.7, 98.7) | (3.41, 5.46) | |
| Predicted risk ≥20% | 78 | 34 | 89.7 | 87.7 | 69.6 | 96.4 | 7.30 |
| 9 | 243 | (81.3, 95.2) | (83.3, 91.3) | (60.2, 78.0) | (93.3, 98.4) | (5.29, 10.09) | |
| Predicted risk ≥30% | 75 | 25 | 86.2 | 91.0 | 75.0 | 95.5 | 9.55 |
| 12 | 252 | (77.1, 92.7) | (87.0, 94.1) | (65.3, 83.1) | (92.2, 97.6) | (6.51, 14.01) | |
| Predicted risk ≥40% | 75 | 12 | 86.2 | 95.7 | 86.2 | 95.7 | 19.90 |
| 12 | 265 | (77.1, 92.7) | (92.6, 97.7) | (77.1, 92.7) | (92.6, 97.7) | (11.37, 34.83) | |
| Predicted risk ≥50% | 71 | 4 | 81.6 | 98.6 | 94.7 | 94.5 | 56.51 |
| 16 | 273 | (71.9, 89.1) | (96.3, 99.6) | (86.9, 98.5) | (91.2, 96.8) | (21.25, 150.28) | |
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; LR+, positive likelihood ratios; CI, confidence interval; IOTA SR, International Ovarian Tumor Analysis Simple Rules.