Table 5.
Diagnostic indices of the combined IOTA Simple Rules models for postmenopausal women.
| Malignant | Benign | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | |
|---|---|---|---|---|---|---|---|
| n | n | (95%CI) | (95%CI) | (95%CI) | (95%CI) | (95%CI) | |
| Postmenopausal women (n = 115) | |||||||
| IOTA SR–refer women with inconclusive results | |||||||
| Malignant and inconclusive | 45 | 12 | 77.6 | 78.9 | 78.9 | 77.6 | 3.69 |
| Benign | 13 | 45 | (64.7, 87.5) | (66.1, 88.6) | (66.1, 88.6) | (64.7, 87.5) | (2.19, 6.21) |
| IOTA SR X CA-125 for postmenopausal women | |||||||
| Predicted risk ≥10% | 57 | 9 | 98.3 | 84.2 | 86.4 | 98.0 | 6.22 |
| 1 | 48 | (90.8, 100.0) | (72.1, 92.5) | (75.7, 93.6) | (89.1, 99.9) | (3.41, 11.35) | |
| Predicted risk ≥20% | 56 | 8 | 96.6 | 86.0 | 87.5 | 96.1 | 6.88 |
| 2 | 49 | (88.1, 99.6) | (74.2, 93.7) | (76.8, 94.4) | (86.5, 99.5) | (3.61, 13.10) | |
| Predicted risk ≥30% | 55 | 7 | 94.8 | 87.7 | 88.7 | 94.3 | 7.72 |
| 3 | 50 | (85.6, 98.9) | (76.3, 94.9) | (78.1, 95.3) | (84.3, 98.8) | (3.85, 15.49) | |
| Predicted risk ≥40% | 55 | 6 | 94.8 | 89.5 | 90.2 | 94.4 | 9.01 |
| 3 | 51 | (85.6, 98.9) | (78.5, 96.0) | (79.8, 96.3) | (84.6, 98.8) | (4.22, 19.25) | |
| Predicted risk ≥50% | 55 | 5 | 94.8 | 91.2 | 91.7 | 94.5 | 10.81 |
| 3 | 52 | (85.6, 98.9) | (80.7, 97.1) | (81.6, 97.2) | (84.9, 98.9) | (4.67, 25.02) | |
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; LR+, positive likelihood ratios; CI, confidence interval; IOTA SR, International Ovarian Tumor Analysis Simple Rules.