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. 2021 Jan 30;13(2):463. doi: 10.3390/nu13020463

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mg deficit, inflammation, oxidative stress, and aging. The relationship of low Mg status, generated by multiple factors (i.e., low Mg intake and absorption, Mg transport genetic defects, obesity, type 2 diabetes mellitus (T2DM) and cardio-metabolic syndrome, polypharmacotherapy, and alcohol abuse), which may trigger an increased production of free radicals (ROS), oxidative damage, and activation of redox signaling (i.e., NF-KB, AP-1, and other transcription factors). The elevation in oxidative stress may lead to the release of inflammatory mediators conforming a state of chronic low-grade inflammation, which has been proposed to accompany aging and called “inflammaging”. TRPM7: Transient Receptor Potential cation channel, subfamily M, member 7; ROS: reactive oxygen species; NF-KB nuclear factor kappa-light-chain-enhancer of activated B cells; AP-1: activator protein 1; TNF-alpha: tumor necrosis factor-alpha; IL: interleukin; CRP: C-reactive protein.