Table 1.
Manifestations of two siblings affected by autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) disease: variability and similarities.
| Manifestation | Patient 1, Female, 14 Years Old | Patient 2, Male, 19 Years Old |
|---|---|---|
| Hypoparathyroidism | + | + |
| Primary adrenocortical insufficiency | − | + |
| Chronic mucocutaneous candidiasis | + | + |
| Vitiligo | + | − |
| Alopecia | + | + |
| Enamel hypoplasia | + | − |
| Onicodystrophy | + | − |
| Rosaceiforme dermatisis and acne | − | + |
| Autoimmune hepatitis | +/− | − |
| Autoimmune insulitis | + | + |
| Diarrhea/intestinal malabsorption | + | − |
| Growth impairment | + | − |
| Pubertal delay | + | − |