Table 1.
Statistical parameters and data distribution analysis.
| Mean | SD | Median | Range | Variance | Coefficient of Variation (%) | Fold Increase | ||
|---|---|---|---|---|---|---|---|---|
| α-TOH (nM) | Pre | 23,483.4 | 3450.9 | 22,434.6 | 19,181–28,618 | 11,208,207.3 | 14% | 2.27 |
| Post | 53,237.9 | 10,530.0 | 49,653.6 | 40,656–78,248 | 104,358,536.9 | 43% | ||
| α -TOH/Cho # | Pre | 123 | 24.8 | 119 | 84–166 | 577.5 | 20% | 2.36 |
| Post | 291 | 60.9 | 288 | 167–381 | 3486.61 | 20% | ||
| γ-TOH (nM) | Pre | 615.2 | 228.1 | 614.5 | 254–1250 | 48,968.6 | 38% | 0.51 |
| Post | 315.6 | 79.2 | 297.4 | 200–489 | 5909.1 | 13% | ||
| α-TQ (nM) | Pre | 75.8 | 20.1 | 73.5 | 45–111 | 380.0 | 26% | 2.63 |
| Post | 199.7 | 74.9 | 196.6 | 104–366 | 5275.1 | 97% | ||
| α-13’COOH (nM) | Pre | 3.5 | 1.8 | 3.1 | 1–8 | 3.0 | 49% | 1.66 |
| Post | 5.8 | 1.4 | 5.6 | 4–8 | 2.0 | 39% | ||
| M1 (nM) § | Pre | 35.1 | 20.4 | 25.6 | 14.3–85 | 390.8 | 56% | 15.65 |
| Post | 549.2 | 329.6 | 471.4 | 182–1363.3 | 102,250.2 | 58% | ||
| M2 (nM) § | Pre | 11.5 | 6.3 | 11.2 | 4.5–24.7 | 37.2 | 53% | 8.89 |
| Post | 102.3 | 76.8 | 73.9 | 31.5–355.9 | 5556.7 | 73% | ||
| α-13’OH (nM) | Pre | 2.6 | 2.1 | 1.7 | 0.4–6.9 | 4.1 | 86% | 7.23 |
| Post | 18.8 | 8.7 | 16.8 | 8–41.5 | 70.6 | 46% | ||
| M3 (nM) * | Pre | 3.0 | 0.9 | 3.0 | 1–4.6 | 0.8 | 31% | 1.97 |
| Post | 5.9 | 2.8 | 5.1 | 2.3–10.3 | 7.2 | 46% | ||
| α-CMBHC (nM) | Pre | 11.0 | 7.3 | 11.6 | 0.6–27.6 | 49.9 | 66% | 11.29 |
| Post | 124.2 | 107.4 | 84.8 | 15.7–392.8 | 10,818.2 | 86% | ||
| α-CEHC (nM) | Pre | 20.3 | 11.6 | 19.0 | 6.2–44.6 | 126.7 | 57% | 20.83 |
| Post | 422.8 | 224.2 | 371.0 | 93–824.7 | 47,121.9 | 53% | ||
| γ-CEHC (nM) | Pre | 102.1 | 37.5 | 102.2 | 50.9–172.9 | 1297.7 | 37% | 1.69 |
| Post | 172.7 | 77.1 | 153.1 | 87.4–303.5 | 5571.9 | 45% | ||
| PXR | Pre | 0.6 | 0.3 | 0.57 | 0–1.14 | 0.09 | 53% | 1.20 |
| Post | 0.72 | 0.29 | 0.82 | 0.2–1.0 | 0.07 | 39% | ||
| CYP4F2 | Pre | 1.30 | 0.88 | 1.09 | 0.2–3.2 | 0.73 | 68% | 0.9 |
| Post | 1.17 | 0.75 | 1.18 | 0–2.2 | 0.52 | 64% | ||
Cho: Cholesterol. Coefficient of variation (%) is calculated using the formula: (SD/average) * 100. # In the α-TOH/Cholesterol ratio, α-TOH levels were in nM and cholesterol levels were in mg/dl. § Quantification was in nmol/l of α-13’COOH equivalents; * Quantification was in nmol/l of α-13’OH equivalents.