Table 4.
Gene symbol and importance scores of 71 hyper-down genes in gene expression classifier and gene methylation classifiers.
| Importance of 71 Hyper-Down Genes Based on Gene Expression Level | Importance of 71 Hyper-Down Genes Based on DNA Methylation Level of All Regions | Importance of 71 Hyper-Down Genes Based on DNA Methylation Level of Dominant Regions | |||
|---|---|---|---|---|---|
| Gene Symbol | Importance | Gene Symbol | Importance | Gene Symbol | Importance |
| PRPH | 100.00 | CNR2 | 100.00 | CCDC33 | 100.00 |
| POU6F2 | 85.32 | KANK3 | 74.12 | LRRC66 | 99.79 |
| CNR2 | 83.29 | GNMT | 62.55 | RASGEF1B | 99.50 |
| SALL4 | 76.54 | C10orf95 | 60.54 | TPO | 72.35 |
| CNTD1 | 55.23 | KCNA7 | 57.28 | MRPL13 | 65.64 |
| TPO | 50.37 | LTV1 | 54.06 | ENPP3 | 64.41 |
| GLDC | 47.41 | TDRD12 | 50.59 | SLC18A1 | 63.26 |
| KLHDC9 | 46.57 | HLA.DQA2 | 48.45 | MMP20 | 58.84 |
| KCNA7 | 36.31 | KLF2 | 48.39 | FUT8 | 58.82 |
| SYNJ2BP | 36.05 | PRR7 | 45.75 | RPLP0 | 58.62 |
| MMP20 | 36.04 | ZNF514 | 43.97 | RBM20 | 57.46 |
| PRR7 | 32.64 | AKR1C3 | 42.20 | NKX3.2 | 56.05 |
| ROR2 | 32.18 | SLC18A1 | 41.67 | SOX7 | 55.14 |
| LRRC66 | 32.14 | ZNF257 | 41.42 | KLF2 | 53.79 |
| SYN3 | 30.43 | ENPP3 | 40.57 | QRSL1 | 53.50 |
| ULBP1 | 29.59 | POU6F2 | 39.64 | LIG1 | 48.87 |
| PLCZ1 | 28.68 | XCL1 | 38.70 | AKR1C3 | 45.54 |
| CATSPERB | 24.22 | QRSL1 | 37.29 | SIRT4 | 45.32 |
| ZNF165 | 23.93 | BOLA3 | 36.98 | YLPM1 | 43.38 |
| P2RX4 | 20.28 | SOX7 | 36.74 | PRPH | 41.58 |
| GIMAP7 | 19.69 | FGF9 | 34.30 | PLEKHA1 | 41.24 |
| NKX3.2 | 19.57 | SYTL2 | 34.13 | SYNJ2BP | 40.67 |
| CSNK2A1 | 19.37 | TBX21 | 33.91 | FGF9 | 40.42 |
| LIG1 | 18.73 | MRPL13 | 33.58 | KLHDC9 | 39.15 |
| C10orf95 | 18.64 | TNIP3 | 32.47 | SYTL2 | 37.12 |
| HOXD11 | 14.99 | C1orf204 | 32.40 | CATSPERB | 35.66 |
| MRPL13 | 14.29 | EXTL2 | 32.37 | GSTA4 | 31.31 |
| BRDT | 12.75 | GRHL2 | 30.95 | GNMT | 30.86 |
| SYTL2 | 12.32 | MMP20 | 30.93 | KANK3 | 30.20 |
| RBM20 | 12.02 | RASGEF1B | 30.61 | ROR2 | 28.88 |
| SPARCL1 | 11.97 | CATSPERB | 29.19 | P2RX4 | 28.65 |
| ZNF514 | 11.36 | C16orf52 | 27.04 | CXCL13 | 27.97 |
| GRHL2 | 11.27 | SIRT4 | 25.34 | HLA.DQA2 | 27.92 |
| SLC18A1 | 11.15 | GLDC | 24.13 | BOLA3 | 26.26 |
| GNMT | 10.75 | CXCL13 | 24.12 | LTV1 | 25.90 |
| LRRC3B | 10.62 | FUT8 | 22.93 | GIMAP7 | 25.73 |
| GZMA | 10.06 | SYNJ2BP | 21.97 | FAM118A | 25.50 |
| FAM118A | 9.29 | KLHDC9 | 21.81 | GRHL2 | 24.98 |
| TDRD12 | 9.01 | KLHDC4 | 21.53 | CSNK2A1 | 24.97 |
| RPLP0 | 8.89 | GIMAP7 | 20.03 | HOXD11 | 24.96 |
| CXCL13 | 8.53 | TSSK3 | 19.54 | BRDT | 24.18 |
| CCDC33 | 8.53 | HOXD11 | 18.13 | C10orf95 | 23.17 |
| ZNF257 | 8.03 | BRDT | 17.55 | C1orf204 | 23.08 |
| C1orf204 | 7.90 | PRPH | 16.54 | XCL1 | 23.02 |
| BOLA3 | 7.60 | CSNK2A1 | 15.97 | TSSK3 | 22.30 |
| TSSK3 | 7.59 | TPO | 15.85 | CNR2 | 21.92 |
| KANK3 | 7.51 | NKX3.2 | 14.99 | TNIP3 | 21.08 |
| ENPP3 | 6.89 | RBM20 | 14.11 | WDR63 | 20.39 |
| GSTA4 | 6.80 | PDPR | 13.91 | OOEP | 19.69 |
| AKR1C3 | 6.75 | LRRC66 | 12.73 | KLHDC4 | 19.50 |
| KLHDC4 | 6.28 | SPARCL1 | 12.28 | GLDC | 19.26 |
| EXTL2 | 5.85 | CNTD1 | 12.28 | SPARCL1 | 19.17 |
| SIRT4 | 5.50 | FAM118A | 12.22 | GZMA | 18.74 |
| FGF9 | 5.22 | CCDC33 | 11.64 | PLCZ1 | 18.74 |
| SCG5 | 4.88 | YLPM1 | 11.39 | SCG5 | 17.37 |
| FUT8 | 4.51 | RPLP0 | 9.51 | POU6F2 | 16.12 |
| OOEP | 4.45 | PLEKHA1 | 9.49 | PDPR | 15.66 |
| TNIP3 | 4.44 | LIG1 | 9.40 | PRR7 | 15.27 |
| PDPR | 4.43 | LRRC3B | 9.20 | EXTL2 | 14.63 |
| PLEKHA1 | 4.29 | ZNF165 | 8.61 | ZNF165 | 13.83 |
| SOX7 | 3.97 | GSTA4 | 7.98 | LRRC3B | 13.70 |
| C16orf52 | 3.90 | SYN3 | 7.58 | SYN3 | 13.64 |
| RASGEF1B | 3.56 | SALL4 | 7.46 | SALL4 | 13.33 |
| WDR63 | 3.54 | SCG5 | 6.31 | ULBP1 | 12.34 |
| TBX21 | 2.92 | ULBP1 | 6.12 | TDRD12 | 12.16 |
| HLA.DQA2 | 2.77 | OOEP | 5.27 | ZNF514 | 8.22 |
| KLF2 | 2.76 | WDR63 | 4.40 | C16orf52 | 7.70 |
| LTV1 | 2.35 | PLCZ1 | 3.34 | TBX21 | 7.52 |
| QRSL1 | 1.46 | GZMA | 2.84 | CNTD1 | 7.11 |
| XCL1 | 0.72 | ROR2 | 0.52 | KCNA7 | 5.55 |
| YLPM1 | 0.00 | P2RX4 | 0.00 | ZNF257 | 0.00 |