Table 1.

Selection of some endolysins and their administration routes.

Target Pathogen	Phage	Enzyme (Endolysin)	Activity (Mode of Action)	Administration Route	References
Streptococcus pneumoniae	Cp1	Cpl-1	Muramidase	Intravenous, nasal, oral, aerosols, and Intraperitoneal	[17,150,151,152,153,154]
	Dp-1	Pal	Amidase	Nasal and oral	[50,155]
	CP-7	Cpl-7	Muramidase	Immersion	[156,157]
Streptococcus pyogenes	C1	PlyC	Amidase	Oral, nasal	[16]
	MGAS5005 prophage	PlyPy	Endopeptidase	Intraperitoneal	[158]
Streptococcus agalactiae	NCTC11261	PlyGBS	Endopeptidase and Muramidase	Intravaginal, oral and intranasal	[159]
	SK1249 prophage	PlySK1249	Amidase and endopeptidase	Intraperitoneal	[160]
MRSA	GH15	LysGH15	Amidase and endopeptidase	Intravenous and Intraperitoneal	[123,161]
	MR11	MV-L	Amidase and endopeptidase	Intraperitoneal, nasal	[141]
	K	LysK	Amidase and endopeptidase	Intraperitoneal	[162]
	SAP-1	SAL-1	Amidase and endopeptidase	Intravenous	[18]
	phiSH2 prophage	phiSH2	Amidase and endopeptidase	Intraperitoneal	[162]
	phiP68	P68	Amidase and endopeptidase	Intraperitoneal	[162]
	phiWMY	LysWMY	Amidase and endopeptidase	Intraperitoneal	[162]
	phi80α	80αLyt2	Amidase and endopeptidase	Intraperitoneal	[162]
	phi11	phi11	Amidase and endopeptidase	Intraperitoneal	[162]
	2854 prophage	2638A	Amidase and endopeptidase	Intraperitoneal	[162]
Pseudomonas aeruginosa	phage PVP-SE1	Artilysin® Engineered Endolysin-Based (PVP-SE1gp146)	Muramidase	Oral and topical	[79]
	P. aeruginosa phage	PlyPa03	Muramidase	Topical	[163]
	P. aeruginosa phage	PlyPa91	Muramidase	Intranasal	[163]
Acinetobacter baumannii	RL-2015	PlyF307	Muramidase	Intraperitoneal and Topical	[164]
	SS3e	LysSS	Muramidase	Intraperitoneal	[165]
Bacillus anthracis	γ-phage	PlyG	Amidase	Intraperitoneal	[93]
Enterococcus faecalis	E. faecalis phage IME-EF1	LysIME-EF1	Endopeptidase	Intraperitoneal	[166]
	E. faecalis phage EF-P10	LysEF-P10	Endopeptidase	Intraperitoneal	[167]