Table 2.
Pharmacokinetic profiles for meloxicam (n = 22) and flunixin (n = 44) based on data sets identified by the present study.
| Route | Dose, mg/kg | T1/2, h | Tmax, h | Vd or Vd/F, L/kg | CL or CL/F, L/h/kg | n | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Min | Max | Min | Max | Min | Max | Min | Max | |||
| Meloxicam | ||||||||||
| IV | 0.5 | 20.4 | 21.9 | - | - | 0.18 | 0.18 | 0.10 | 0.11 | 2 |
| PO | 0.5–1.0 | 11.9 | 40.0 | 11.3 | 24.0 | 0.16 | 0.38 | 0.09 | 0.22 | 16 * |
| SC | 0.5 | 8.95 | 24.7 | 3.70 | 6.00 | 0.07 | 0.18 | 0.08 | 0.13 | 4 |
| Flunixin | ||||||||||
| IV | 1.1-2.2 | 3.14 | 12.9 | - | - | 0.38 | 25.2 | 1.12 | 4.70 | 24 |
| IM | 1.1-2.2 | 1.87 | 15.5 | 0.25 | 3.10 | - | - | - | - | 9 * |
| PO | 2.2 | - | - | - | - | - | - | - | - | 1 * |
| SC | 2.0-2.2 | 4.50 | 7.46 | 1.10 | 3.47 | - | - | - | - | 4 * |
| TD | 3.3 | 6.42 | 13.2 | 1.66 | 2.14 | 3.05 | 7.47 | 5.49 | 6.52 | 6 * |
IV = intravenous; PO = per os (oral); SC = subcutaneous; IM = intramuscular; TD = transdermal; T1/2 = apparent terminal half-life; Tmax = time at maximum concentration; Vd = volume of distribution; /F = per fraction absorbed; CL = clearance; n = number of datasets; * Excludes multiple dose studies.