Table 1.
Infectivity and replication of chimeric H7N9+4M2e and its H7N9 counterpart in mice.
Virus | MID50, log10 EID50 | Infectious Virus Titer 3 dpi at Indicated Dose | ||||
---|---|---|---|---|---|---|
7.0 log10 EID50 | 6.0 log10 EID50 | |||||
Nasal Turbinate | Lung | Nasal Turbinate | Lung | Nasal Turbinate | Lung | |
H7N9 | 4.5 | ≥6 | 3.6 ± 1.1 | 1.6 ± 0.3 | 2.7 ± 1.8 | 2.1 ± 0.5 |
H7N9+4M2e | 4 | ≥6 | 3.7 ± 0.5 | 1.3 ± 0.2 | 3.1 ± 0.6 | 1.4 ± 0.3 |