Table 1.
Primary Analysis: MCIDs for Two Measures of Cognitive Function
| # RCTs (# Participants) |
SD Range | Pooled SD | MCID: 0.4 x SD |
MCID: 0.5 x SD |
|
|---|---|---|---|---|---|
| MMSE | |||||
| Baseline SDs | 51 (12449) | 0.94 to 6.80 | 4.0 | 1.6 | 2.0 |
| Mean Change SDs | 36 (10575) | 0.33 to 6.12 | 3.6 | 1.4 | 1.8 |
| ADAS-Cog | |||||
| Baseline SDs | 37 (10006) | 2.55 to 17.30 | 10.0 | 4.0 | 5.0 |
| Mean Change SDs | 38 (13288) | 1.32 to 12.85 | 6.4 | 2.6 | 3.2 |
Abbreviations: Alzheimer Disease Assessment Scale – Cognitive Subscale (ADAS-Cog), minimum clinically important difference (MCID), Mini-Mental State Exam (MMSE), randomized trial (RCT), standard deviation (SD), number (#)